Combined application of montmorillonite powder and Kangfuxin liquid for the treatment of stomatitis complicated by oral ulcer in 62 patients / 中国基层医药

Objective:To investigate the clinical application value of montmorillonite powder combined with Kangfuxin liquid in the treatment of stomatitis complicated by oral ulcer. Methods:A total of 124 patients with stomatitis complicated by oral ulcer who received treatment in Zhoushan Women and Children Hospital, China between January 2019 and October 2020 were included in this study. They were randomly assigned to receive treatment either with montmorillonite powder alone (control group, n = 62) or montmorillonite powder and Kangfuxin liquid (observation group, n = 62). Visual Analogue Scale score before and after treatment, duration of ulcer pain and wound recovery time, curative effect and adverse reactions were compared between the two groups. Results:After treatment, Visual Analogue Scale score in each group was significantly decreased compared with before treatment ( t = 5.862, 8.223, both P < 0.05). After treatment, Visual Analogue Scale score in the observation group was significantly lower than that in the control group [(0.72 ± 0.23) points vs. (1.22 ± 0.47) points, t = 2.667, P < 0.05]. The time to ulcer pain relief and the time to wound recovery in the observation group were significantly shorter than those in the control group ( t = 3.467, 2.667, both P < 0.05). Effective rate in the observation group was significantly higher than that in the control group [96.77% (60/62) vs. 85.48% (53/62), χ2 = 4.888, P < 0.05]. There were no adverse reactions in each group. Conclusion:Combined application of montmorillonite powder and Kangfuxin liquid for the treatment of stomatitis complicated by oral ulcer can effectively mitigate wound pain, accelerate wound healing, and improve the quality of life. This study is of significant innovation and science. Therefore, the treatment method used in this study is worthy of clinical promotion.

Application of individualized and staged psychological intervention in liver cancer patients during perioperative period / 中国实用护理杂志

Objective:To explore the application of individualized and staged psychological intervention in liver cancer patients during perioperative period, to provide reference for perioperative nursing of patients with liver cancer.Methods:A total of 80 liver cancer patients who were hospitalized in Hefei Binhu Hospital and Hefei First People's Hospital from January to December 2019 were divided into observation group and control group by random number table method, with 40 cases in each group. The control group was given routine perioperative care, and the observation group was treated with routine perioperative care and individualized phased psychological intervention. All were intervented for 7 days. The mental state, self-efficacy, quality of life, and psychosocial adaptation levels before and after the intervention were evaluated by Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), and General Self-Efficacy Scale (GSES), the Quality of Life Scale, etc.Results:There was no significant difference in HAMA, HAMD, GSES, quality of life, and psychosocial adaptation level between the two groups before intervention ( P>0.05). The HAMA and HAMD scores in the observation group after intervention were (16.01 ± 2.25) and (15.75 ± 2.06) points, which were lower than those in the control group (18.46 ± 2.49) and (17.29 ± 2.33) points, and the differences were statistically significant ( t values were 4.617, 3.312, P<0.05). The overall function scores of GSES and quality of life in the observation group after intervention were (28.49 ± 3.82) and (46.41 ± 4.63) points, which were higher than those in the control group (25.35 ± 3.64) and (43.74 ± 4.95) points, the differences were statistically significant ( t values were 3.764, 2.491, P<0.05); all aspects of psychosocial adaptation scores in the observation group after intervention were higher than those in the control group, the differences were statistically significant ( t values were 2.278 - 4.578, P<0.05). Conclusions:The application of individualized and staged psychological intervention in liver cancer patients during perioperative period can significantly alleviate negative emotion, enhance their self-efficacy, improve level of social-psychological adjustment and quality of life.

Fire prevention management and practice of data room in hospital / 医疗卫生装备

Objective To explore the fire prevention management to ensure the operating of the data room in the hospital. Methods The hidden risks in the fire prevention of the data room were pointed out in auto fire fighting system,precision air-conditioning equipment, UPS and battery pack, compatibilization and expansion, high-voltage power supply circuit, lightningproof grounding and etc.It's indicated that the maintenance staff had deficiency in mastering related knowledge on gas fire-extinguishing system.Results The maintenance had to be strengthened for the auto fire fighting system,precision air-conditioning equipment,UPS and battery pack,and the detection should be reinforced for the high-voltage power supply circuit and lightningproof grounding system. It's suggested that standardized construction be executed during data room compatibilization and expansion,corresponding management system be established,and the knowledge be mastered on the composition,operation and announcements.Conclusion The fire prevention management of the data room is enhanced in the hospital,and the hidden risks are eliminated for fire fighting.

Lai’s Tongyuan Acupuncture Therapy in Treatment of Depressive Neurosis / 沈阳医学院学报

Objective:To observe the effects of Lai’s Tongyuan acupuncture therapy on depressive neurosis.Methods:A total of 38 patients with depressive neurosis were randomized into the control group and treatment group. On basis of oral Fluoxetine hydrochloride, the control group was given common acupuncture method, the treatment group was given Lai’s Tongyuan acupuncture therapy. The scores of HAMD and ADR were observed after treating 4 weeks, 8 weeks and 12 weeks. Results:The scores of HAMD in 2 groups were significantly lower than before, the scores of HAMD and SDS in the treatment group was significantly lower than that in the control group (P<0.05).Conclusion:Lai’s Tongyuan acupuncture therapy has better effects for depressive neurosis patients in clinical efficacy.

Value of serum miR-155 in the diagnosis and prognosis of pancreatic cancer / 中华肝胆外科杂志

Objective To investigate the diagnostic and prognostic value of serum miR-155 for pancreatic cancer.Methods A total of 110 pancreatic cancer patients,70 chronic pancreatitis and 58 healthy individuals who admitted to the First People's Hospital of Hefei between January 2009 and August 2013 were prospectively enrolled.Their serum miR-155 levels were detected by real-time PCR.The receiver operating characteristic curve was employed to estimate the diagnostic accuracy of miR-155 for pancreatic cancer.Correlations between miR-155,carbohydrate antigen 19-9 (CA 19-9) and TNM stages were analyzed.The Kap1an-Meier approach and the Cox model were used to assess the prognostic value of miR-155 for pancreatic cancer.Results Pancreatic cancer patients had significantly higher serum miR-155 when compared either with chronic pancreatitis patients or healthy individuals (P ＜ 0.05 for both).The areas under the receiver operating characteristic curve were 0.82 (95％ CI:0.75 ～ 0.88) for miR-155,and 0.88 (95％ CI:0.82 ～0.93) for miR-155 combined with CA19-9.MiR-155 increased as the TNM stages advanced,and it was positively correlated with CA 19-9 (R2 =0.22,P ＜ 0.05).MiR-155 ≥ 1.46 △CT was independently associated with pancreatic cancer mortality,with a hazard ration of 2.88 (95％ CI:1.26 ～ 6.58).Conclusion Serum miR-155 is a useful biomarker for diagnosis and prognosis of pancreatic cancer.

A new erythrodiol triterpene fatty ester from Scorzonera mongolica / 药学学报

Two erythrodiol triterpene fatty esters, 3beta-dodecanoyl erythrodiol (1) and 3beta-tetradecanoyl erythrodiol (2), were isolated from Scorzonera mongolica. Their structures were elucidated on the basis of IR, MS and extensive 2D NMR spectroscopic analysis. Compound 1 was identified to be a new compound and 2 was confirmed to be a new natural compound. Their antitumor effects in vitro were evaluated with MTT and SRB assays, but compounds 1 and 2 only showed moderate cytotoxicities on A-549 cell line.

Effect of electrical stimulation of the primary auditory cortex on the spontaneous activities of the external nucleus of the inferior colliculus in a rat model of tinnitus induced by salicylate acid / 生理学报

This study aims to investigate corticofugal modulation on spontaneous activities of the external nucleus of the inferior colliculus (ICx) in a salicylate acid (SA) induced tinnitus rat model by the stimulation of the primary auditory cortex (AI). Extracellular recording techniques and stereotaxic method were used. The spontaneous activities of a single unit were recorded from the left ICx after electrical stimulation was given to the left AI of the rats duplicated as acute SA models. The average rate of spontaneous discharge and the interspike interval histogram of spontaneous activities were used as indices. The single unit spontaneous discharges of the same unit of ICx before and after AI stimulation were observed. There was an inhibitory effect of AI stimulation on the activities of the high discharge unit [(8.75+/-2.70) Hz vs (5.06+/-2.01) Hz] and a facilitatory effect on the low discharge unit [(1.41+/-0.45) Hz vs (2.46+/-0.79) Hz]. In the normal group, there was a restraining effect on the average rate of spontaneous discharge of the ICx after AI stimulation. The average rate of spontaneous discharge changed from (3.66+/-0.84) Hz to (2.47+/-0.43) Hz in the first hour after AI stimulation and then recovered within 2-4 h. And the discharge rate of the spike interval within 0-20 ms decreased (17% vs 7.3%, 11.2%) in the first 2 h and recovered 3-4 h after AI stimulation. The discharge rate of the spike interval within 0-6 ms (short interval) recovered 2 h after AI stimulation. In the acute SA model group, the average rate of spontaneous discharge recorded from the ICx decreased from (7.48+/-0.85) Hz to (3.38+/-0.39) Hz in the first hour after AI stimulation and the suppression effect remained 4 h (P<0.05). There was no difference in the average rate of spontaneous discharge between the acute SA model group and the normal group at 2-4 h after AI stimulation. The suppression effect after AI stimulation on the 0-20 ms interval spikes in the ICx lasted 4 h, while that on the shorter interval (0-6 ms) spikes recovered in the 3rd hour after AI stimulation in acute SA model group. It is concluded that the high average spontaneous discharge rate of ICx in acute SA model decreases significantly by AI stimulation, and the suppression effects on the shorter interval spikes recovers in the 3rd hour after AI stimulation. It might be inferred that stimulation of AI, through exciting the auditory descending projections, could remit the increased spontaneous discharge of ICx induced by SA that may relate with tinnitus in a period of time.

Effects of er-long-zuo-ci-wan on the spontaneous activities of auditory central nucleus in rat model of tinnitus induced by salicylate acid / 中国应用生理学杂志

<p><b>AIM</b>Observe the effects of er-long-zuo-ci-wan (EIZCW, a compound of Chinese Traditional Medicine) on the spontaneous discharge of external cortex of inferior colliculus (ICx) and secondary auditory cortex (AII) of chronic tinnitus model rats induced by salicylate acid, to explore the neural mechanisms underlying ELZCW preventing tinnitus.</p><p><b>METHODS</b>30 adult SD rats were involved and divided into three groups, normal control group, chronic tinnitus model group and ELZCW prevention group. Extracellular recording techniques and stereotaxic method were used. The spontaneous spikes were recorded and analyzed from ICx and all in different group rats. The average rate of spontaneous discharge and the interspike interval histogram of spontaneous activities were used as indexes.</p><p><b>RESULTS</b>(1) Compared with normal control group, the average rate of spontaneous discharge recorded from the ICx in the chronic tinnitus model group increased significantly (4.57 +/- 0.54 Hz vs. 3.14 +/- 0.40 Hz, P < 0.05). Furthermore analysis showed that the discharge rate of short spike interval from the ICx in the chronic tinnitus model group increased than that of the normal group (0-40 ms: 58% vs. 40%; 0-4 ms: 9% vs. 5%). And there was an increasing tendency of the average rate of spontaneous discharge recorded from the AII in the chronic tinnitus model group compared with that in the normal group. (2) Compared with the chronic tinnitus model group, the average rate of spontaneous discharge recorded from the ICx and AII in the ELZCW prevention group significantly decreased than that in the chronic tinnitus model group (ICx: 2.41 +/- 0.21 Hz vs. 4.57 +/- 0.54 Hz, P < 0.01. AII: 2.24 +/- 0.24 Hz vs. 4.57 +/- 0.54 Hz , P < 0.01). And the discharge rate of short spike interval from the ICx and AII in the chronic tinnitus model group decreased than that in the normal control group (ICx: 0-40 ms 50% vs. 58%, 0-4 ms 4% vs. 9%. All: 0-22 ms: 24% vs. 31%, 0-8 ms 19% vs. 16%).</p><p><b>CONCLUSION</b>If the increasing of the spontaneous activities of ICx and AII in chronic tinnitus rats means tinnitus, the use of ELZCW could decrease this kind of changes.</p>

The effect of neoadjuvant chemotherapy on estrogen and progesterone receptor expression in breast carcinoma / 中华外科杂志

<p><b>OBJECTIVE</b>To investigate the effect of neoadjuvant chemotherapy on estrogen receptor (ER) and progesterone receptor (PR) expression in breast carcinoma.</p><p><b>METHODS</b>Samples were obtained from 31 patients with breast carcinoma who received neo-adjuvant chemotherapy, ER or PR expressions were analyzed in preoperative core biopsies and final surgical specimens.</p><p><b>RESULTS</b>ER level was up-regulated in 13 (41.9%) out of 31 cases, PR level was up-regulated in 10 (32.3%). Both ER level and PR level were up-regulated in 8 (25.8%) out of 31 cases.</p><p><b>CONCLUSIONS</b>Neoadjuvant chemotherapy may impact the hormone receptor status, ER and PR expression re-analysis in final surgical specimens is recommended.</p>

Expression and significance of estrogen receptor isoforms in the development of human breast carcinoma / 中华外科杂志

<p><b>OBJECTIVE</b>To investigate the estrogen receptors (ER)alpha and ERbeta expression and their relationship with clinicopathological parameters in human breast carcinoma.</p><p><b>METHODS</b>Samples were obtained from 30 breast carcinoma, reverse transcriptase polymerase chain reaction was used to measure the expression of ERalpha and ERbeta mRNA.</p><p><b>RESULTS</b>ERalpha mRNA level was up-regulated in breast carcinoma tissue compared with adjacent normal tissue (t = 7.399, P < 0.01) while down-regulated in ERbeta. The relative ratio of ERalpha and ERbeta was decreased in normal tissue vs. carcinoma (t = 6.385, P < 0.01), in patients with lymph node metastasis vs. those without lymph node metastasis (t = 2.602, P < 0.05), in late stage carcinoma vs. early stage (t = 3.754, P < 0.05).</p><p><b>CONCLUSION</b>ERalpha and ERbeta play divergent role in the development of human breast carcinoma.</p>

Potential oxidative stress in the bodies of electric arc welding operators: effect of photochemical smog / 生物医学与环境科学（英文）

<p><b>OBJECTIVE</b>To investigate whether photochemical smog emitted during the process of electric arc welding might cause oxidative stress and potential oxidative damage in the bodies of welding operators.</p><p><b>METHODS</b>Seventy electric arc welding operators (WOs) and 70 healthy volunteers (HVs) were enrolled in a randomized controlled study design, in which the levels of vitamin C (VC) and vitamin E (VE) in plasma as well as the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX), and the level of lipoperoxide (LPO) in erythrocytes were determined by spectrophotometry.</p><p><b>RESULTS</b>Compared with the average values of the above experimental parameters in the HVs group, the average values of VC and VE in plasma as well as those of SOD, CAT and GPX in erythrocytes in the WOs group were significantly decreased (P < 0.005-0.0001), while the average value of LPO in erythrocytes in the WOs group was significantly increased (P < 0.0001). The findings from the partial correlation analysis on the controlling of age suggested that with a prolonged duration of exposure to photochemical smog the values of VC, VE, SOD, and GPX, except for CAT, in the WOs were decreased gradually (P < 0.05-0.005), the value of LPO in the WOs was increased gradually (P < 0.001), and that with the ozone dose increased in the air in each worksite VC, VE, SOD, CAT and GPX decreased (P < 0.005-0.001), but LPO increased (P < 0.001). The findings from the reliability analysis for the VC, VE, SOD, CAT, GPX, and LPO values which were used to reflect oxidative stress and potential oxidative damage in the WOs showed that the reliability coefficients' alpha (6 items) was 0.8021, P < 0.0001, and that the standardized item alpha was 0.9577, P < 0.0001.</p><p><b>CONCLUSION</b>Findings in the present study suggest that there exists an oxidative stress induced by long-term exposure to photochemical smog in the bodies of WOs, thereby causing potential oxidative and lipoperoxidative damages in their bodies.</p>

Ozone emitted during copying process--a potential cause of pathological oxidative stress and potential oxidative damage in the bodies of operators / 生物医学与环境科学（英文）

<p><b>OBJECTIVE</b>To estimate the impact of copying on the indoor air quality, and to investigate whether ozone emitted during such a process induces pathological oxidative stress and potential oxidative damage in the bodies of operators.</p><p><b>METHODS</b>67 copying operators (CO) and 67 healthy volunteers (HV) were enrolled in a random control study, in which levels of lipoperoxide (LPO) in plasma and erythrocytes, and levels of vitamin C (VC), vitamin E (VE) and beta-carotene (beta-CAR) in plasma as well as activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) in erythrocytes were determined by spectrophotometric methods.</p><p><b>RESULTS</b>Compared with the HV group, the average values of LPO in plasma and erythrocytes in the CO group were significantly increased (P<0.0001), while those of VC, VE and beta-CAR in plasma as well as those of SOD, CAT and GPX in erythrocytes in the CO group were significantly decreased (P<0.0001). Pearson product-moment correlation analysis showed that with increase of ozone level in copying sites and duration of exposure to ozone, the values of LPO in plasma and erythrocytes in the bodies of operators were gradually increased,while those of VC, VE, beta-CAR, SOD, CAT and GPX were decreased in the same manner. Odds ratio (OR) of risk of biochemical parameters reflecting potential oxidative damage of the copying operators ranged from 4.440 to 13.516, and 95% CI of OR was from 2.113 to 34.061. Reliability coefficient (alpha) of the biochemical parameters used to reflect the potential oxidative damage of the operators was 0.8156, standardized item alpha=0.9929, P<0.0001.</p><p><b>CONCLUSION</b>Findings in the present study suggest that there exist a series of free radical chain reactions and pathological oxidative stress induced by high dose ozone in the operators, thereby causing potential oxidative and lipoperoxidative damages in their bodies.</p>